Just start learning python tools making in Houdini. Knowing that houdini been using PySide2 with Python27 to create UI.And I have pip configured in my Houdini. It's possible to use the latest PySide6 to create UI without compatibility problems? :/

Houdini 20.0 is using QT5(5.15.2), which still uses Pyside2.
On Windows, if you look in C:\Program Files\Side Effects Software\Houdini 20.0.724\bin
you will find all the QT5 dlls.

Hope this helps.

Yes, you can! Also, easily migrate PySide2 code to PySide6 later. Better to stick with built in PySide2 for now.