Hello,

I'm trying to use a wire deformer but I can't get the orientation to work correctly. I've messed with the normals but the results are messy.

I guess it is not working because the wire deform is not using the up vector (but only the tangent of the curve) and it doesn't matter if you have assigned an up vector on the curve.
A possible workaround can be creating a guide geometry (sweep the curve with ribbon transformed and not transformed) and use the point deformer instead.